Rifampicin-Isoniazid 300/150mg Coated Tablets
What Rifampicin-Isoniazid Tablets are used for:
- Rifampicin and Isoniazid are used to treat tuberculosis (also known as TB).
Do not take Rifampicin-Isoniazid Tablets if:
- You are allergic to Rifampicin, Isoniazid or any of the other ingredients of this medicine
- You have yellowing of the skin and eyes (jaundice)
- You are taking saquinavir or ritonavir for an HIV infection
Warnings & Precautions:
- Talk to your doctor or pharmacist before taking Rifampicin-Isoniazid Tablets if:
- You have liver problems
- You have any kidney problems and if you are having more than 600mg rifampicin per day
- You have diabetes
- You have epilepsy
- You have or have ever had mental health problems (such as depression or schizophrenia)
- You feel numb or weak in your arms and legs (peripheral neuropathy)
- You have an HIV infection
- You’re underweight or malnourished
- You drink alcohol every day or you are an alcoholic
- You inject yourself with drugs
- You are a black or Hispanic woman
- You have a rare blood problem called ‘porphyria’
- You have a problem with bleeding or a tendency to bruise easily
- You wear contact lenses.
- The person taking this medicine is a child or aged 65 years or older.
Possible Side Effects:
- You may notice a discoloration (yellow, brown, orange or red colour) in your teeth, urine, sweat, phlegm (sputum), saliva or tears.
- This is quite common and you don't need to worry. However, the colour may permanently stain soft contact lenses.
- The colour in tears may last for some time after you have stopped having Rifampicin-Isoniazid Tablets.
Other medicines and Rifampicin-Isoniazid Tablets:
- In particular, do not take this medicine, and tell your doctor, if you are taking:
- Saquinavir or ritonavir used for HIV infection
- The following medicines can make Rifampicin-Isoniazid Tablets work less well:
- Antacids used for indigestion. Take Rifampicin-Isoniazid Tablets at least 1 hour before taking antacids
- Other medicines used for TB such as P-aminosalicyclic acid (PAS) and cycloserine. PAS and Rifampicin-Isoniazid Tablets should be taken at least 8 hours apart
- Tell your doctor if you are taking any of the following medicines:
- Heart and blood medicines
- Mental health, epilepsy and motor neurone medicines
- Medicines for infections and the immune system
- Hormone and cancer medicines
- Pain and inflammation medicines
- Medicines used for diabetes
- Medicines used to relax muscles before surgery (anaesthetics) such as halothane
- Some medicines used for feeling sick or being sick such as ondansetron and aprepitant
- Other antibiotic medicines such as cefazolin
- Quinine - used for malaria
- Theophylline - used for wheezing or difficulty in breathing
How to take Rifampicin-Isoniazid Tablets:
- Take this medicine by mouth
- Swallow the tablets whole, with a drink of water
- Take at least 30 minutes before a meal or 2 hours after a meal. They are best taken at least 30 minutes before breakfast
- Take all your tablets together each day, as a single dose
- Do not give this medicine to children
- If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor
- Your doctor may ask you to take Vitamin B6 during treatment with Rifampicin-Isoniazid Tablets, especially if you are malnourished, elderly or a diabetic.
- Adults and the Elderly weighing more than 50kg
- Two tablets each day
- If you are elderly, your doctor may monitor your treatment more closely
- Adults and the Elderly weighing less than 50kg
- Rifampicin-Isoniazid 150/100mg Tablets are usually prescribed
- Children
- This medicine is not recommended for use in children.
How to store Rifampicin-Isoniazid Tablets:
- Keep this medicine in a safe place where children cannot see or reach it.
- Do not use Rifampicin-Isoniazid Tablets after the expiry date which is stated on the carton and blister packs.
- The expiry date refers to the last day of that month.
- Store below 25°C. Keep the blister in the outer carton, protect from moisture.
* Dosage form and route of administration of Rifampicin-Isoniazid 150/100mg Coated Tablets should be prescribed according to therapeutic indication and disease severity of each individual patient.