Product Description:

Paquix contains the active substance apixaban and belongs to a
group of medicines called anticoagulants. This medicine helps to prevent blood
dots from forming by blocking Factor Xa which is an important component of
blood clotting.

Paquix is used in adults:

• To prevent blood clots (deep
  vein thrombosis [DVT]) from forming after hip or knee replacement
  operations. After an operation to the hip or knee you may be at a higher
  risk of developing blood clots in your leg veins. This can cause the legs
  to swell, with or without pain. If a blood clot travels from your leg to
  your lungs, it can block blood flow causing breathlessness, with or
  without chest pain. This condition (pulmonary embolism) can be
  life-threatening and requires immediate medical attention.



• To prevent a blood clot from
  forming in the heart in patients with an irregular heart beat (atrial
  fibrillation) and at least one additional risk factor. Blood dots may
  break off and travel to the brain and lead to a stock or to other organs
  and prevent normal blood flow to that organ (also known as a systemic
  embolism). A stroke can be life-threatening and require immediate medical
  attention.



• To treat blood dots in the
  veins of your legs (deep vein thrombosis) and in the blood vessels of your
  lungs (pulmonary embolism), and to prevent blood clots from re-occurring
  in the blood vessels of your legs and\or lugs.

How to use:Always take this medicine exactly as your doctor or pharmacist has
told you. Check with your doctor, pharmacist or nurse if you are not sure.

To prevent a blood clot from forming in the heart in patients with
an irregular heartbeat and at least one additional risk factor.

• The recommended dose is one tablet of Paquix 5 mg twice a day.
• The recommended
  dose is one tablet of Paquix 2.5 mg twice a day if,




• You have severely reduced
  kidney function.

• Two or more of the following
  apply to you: Your blood test results suggest poor kidney function (value
  of serum creatinine is 1.5 mg/dL (133 micromole\L) or greater)

• You are 80 years old or older.

• Your weight is 60 kg or lower.

• The recommended dose is one
  tablet twice a day, for example, one in the morning and one in the
  evening. Try to take the tablets at the same times every day to have the
  best treatment effect.

Swallow the tablet with a drink of water. Paquix can be taken with
or without food.

Your doctor will decide how long you must continue treatment.

For preventing blood clots from re-occurring following completion
of 6 months of treatment; The recommended dose is one tablet of Paquix 2.5 mg
twice a day for example one in the morning and one in the evening. Try to take
the tablets at the same times every day to have the best treatment effect.

Caution & Warnings:

a. Do not take Paquix if:

• You are allergic to apixaban or
  any of the other ingredients of this medicine.



• You are bleeding excessively.



• You have a disease in an organ
  of the body that increase the risk of serious bleeding (such as an active
  or a recent ulcer at your stomach or bowel. recent bleeding in your
  brain).



• You have a liver disease which
  leads to increased risk of bleeding (hepatic coagulopathy).



• You are taking medicines to
  prevent blood clotting (e.g. warfarin. rivaroxaban, dabigatran or heparin),
  except when changing anticoagulant treatment or while having a venous or
  arterial line and you get heparin through this line to keep it open.

b. Take special care with Paquix

Before taking Paquix, tell your doctor about all of your medical
conditions, including if you have any the following:

• An increased risk of bleeding,
  such as.





• bleeding disorders, including
  conditions resulting in reduced platelet activity



• very high blood pressure, not
  controlled by medical treatment



• you are older than 75 years



• you weigh 60 kg or less





• A severe kidney disease or if
  you are on dialysis.



• A liver problem or a history of
  liver problems Paquix will be used with caution in patients with signs of
  altered liver function.



• If you have a prosthetic heart
  valve.



• If your doctor determines that
  your blood pressure is unstable or another treatment or surgical procedure
  to remove the blood dot from your lungs is planned.

If you need to have surgery or a procedure which may cause
bleeding, your doctor might ask you to temporarily stop taking this medicine
for a short while, If you are not sure whether a procedure may cause bleeding
ask your doctor.

c. Children and adolescents

Paquix is not recommended in children and adolescents under 18
years of age.

d. Taking other medicines, herbal or dietary supplements

Tell your doctor, pharmacist or nurse it you are taking, have
recently taken or might take any other medicines.

Some medicines may increase the effects of Paquix and some may
decrease its effects. Your doctor will decide, if you should be treated with
Paquix when taking these medicines and how closely you should be monitored.

The following medicines may increase the effects of Paquix and
increase the chance for unwanted bleeding:

• Some medicines for fungal
  infections (e.g. ketoconazole, etc.).



• Some antiviral medicines for
  HIV\AIDS (e.g., Ritonavir).



• Other medicines that are used
  to reduce blood clotting (e.g., enoxaparin, etc.).



• Anti-inflammatory or pain
  medicines (e.g. aspirin or naproxen). Especially, if you are older than 75
  years and are taking aspirin. You may have an increased change of
  bleeding.



• Medicines for high blood
  pressure or heart problems (e.g.. diltiazem).

The following medicines may reduce the ability of Paquix to help
prevent blood clots from forming:

• Medicines to prevent epilepsy
  or seizures (e.g. phenytoin. etc.).



• St John’s Wort (a herbal
  supplement used for depression).



• Medicines to treat tuberculosis
  or other infections (e.g. rifampicin)

e. Pregnancy and breast-feeding

PregnancyIf you are pregnant or breast-feeding, think you
may be pregnant ae planning to have a baby, ask your doctor, pharmacist or
nurse for advice before taking this medicine. The effects of Paquix on
pregnancy and the unborn child are not known. You should not take Paquix if you
are pregnant. Contact your doctor immediately if you become pregnant while
taking Paquix.

LactationIt is not known if Paquix passes into human
breast mills. Ask your doctor, pharmacist or nurse for advice before taking
this medicine while breast-feeding. They will advise you to either stop
breast-feeding or to stop/not start taking Paquix.

f. Driving and using machines

Paquix has not been shown to impair your ability to drive or use
machine.

g. Important information about some of the ingredients:

Paquix contains lactose (a type of sugar). It you have been told
by your doctor that you have an intolerance to some sugars, contact your doctor
before taking this medicine.

Ingredients:

Apixaban 5 mg.

Lactose, Microcrystalline Cellulose, Croscarmellose Sodium, Sodium
Lauryl Sulphate, Magnesium Stearate, Opadry White OYL & Yellow Iron Oxide.