Ruxolitinib 20mg Tablets
What Ruxolitinib is used for:
- Ruxolitinib is used to treat adult patients with an enlarged spleen or with symptoms related to myelofibrosis, a rare form of blood cancer. Ruxolitinib is also used to treat patients with polycythaemia vera who are resistant to or intolerant of hydroxyurea.
Do not take Ruxolitinib:
- if you are allergic to Ruxolitinib or any of the other ingredients of this medicine.
- if you are pregnant or breastfeeding.
Warnings & Precautions:
- Talk to your doctor or pharmacist before taking Ruxolitinib
- If you have any infections. It may be necessary to treat your infection before starting Ruxolitinib. It is important that you tell your doctor if you have ever had tuberculosis or if you have been in close contact with someone who has or has had tuberculosis. Your doctor may perform tests to see if you have tuberculosis or any other infections. It is important that you tell your doctor if you have ever had hepatitis B.
- If you have any kidney problems. Your doctor may need to prescribe a different dose of Ruxolitinib.
- If you have or have ever had any liver problems. Your doctor may need to prescribe a different dose of Ruxolitinib.
- If you are taking other medicines.
- If you have ever had tuberculosis.
- If you have ever had skin cancer.
Possible Side Effects:
- Ruxolitinib can cause serious side effects, although not everybody gets them.
- high level of cholesterol or fat in the blood (hypertriglyceridaemia)
- abnormal liver function test results
- dizziness
- headache
- urinary tract infections
- weight gain
- fever, cough, difficult or painful breathing, wheezing, pain in chest when breathing (possible symptoms of pneumonia)
- high blood pressure (hypertension), which may also be the cause of dizziness and headaches
- constipation
- high level of lipase in the blood
Other medicines and Ruxolitinib:
- Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
- It is particularly important that you mention any of the following medicines containing any of the following active substances, as your doctor may need to adjust the Ruxolitinib dose for you.
- Some medicines used to treat infections. These include medicines used to treat fungal diseases (such as ketoconazole, itraconazole, posaconazole, fluconazole and voriconazole), medicines used to treat certain types of bacterial infections (antibiotics such as clarithromycin, telithromycin, ciprofloxacin, or erythromycin)
- medicines to treat viral infections, including HIV infection/AIDS (such as amprenavir, atazanavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir), medicines to treat hepatitis C (boceprevir, telaprevir)
- Nefazodone, a medicine to treat depression
- Mibefradil or diltiazem, medicines to treat hypertension and chronic angina pectoris
- Cimetidine, a medicine to treat heartburn.
How to take Ruxolitinib:
- The recommended starting dose in myelofibrosis is 15 mg twice daily or 20 mg twice daily, depending on your blood cell count.
- The recommended starting dose in polycythaemia vera is 10 mg twice daily.
- The maximum dose is 25 mg twice daily.
- During the treatment your doctor may recommend a lower or higher dose to you if the results of blood tests show that this is necessary, if you have problems with your liver or kidneys, or if you also need treatment with certain other medicines.
How to store Ruxolitinib:
- Keep this medicine out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the carton or blister after “EXP”.
- Do not store above 30°C.