<p><strong>Product Description:</strong></p> <ul> <li>The active ingredient of this drug called Metformin.</li> <li>Metformin XR Extended-Release Tablets are oral antihyperglycemic drugs used in the management of type 2 diabetes.</li> <li>It controls blood sugar (glucose) and helps your body use insulin effectively.</li> <li>This medication is often combined with changes to diet and exercise.</li> <li>This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.</li> </ul> <p><strong>How To Use:</strong></p> <ul> <li>There is no fixed dosage regimen for the management of hyperglycemia in patients with type 2 diabetes with METFORMIN XR .</li> <li>Dosage of METFORMIN XR must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses.</li> <li>The maximum recommended daily dose of METFORMIN XR in adults is 2000 mg.</li> <li>METFORMIN XR should generally be given once daily with the evening meal.</li> <li>METFORMIN XR should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient.</li> </ul> <p>Adults:</p> <ul> <li>The usual starting dose of METFORMIN XR (metformin hydrochloride) Extended-Release Tablets is 500 mg once daily with the evening meal.</li> <li>Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal.</li> <li>If glycemic control is not achieved on METFORMIN XR 2000 mg once daily, a trial of METFORMIN XR &nbsp;1000 mg twice daily should be considered.</li> <li>If higher doses of metformin are required, METFORMIN should be used at total daily doses up to 2550 mg administered in divided daily doses, as described above.</li> </ul> <p><strong>Warnings And precautions:</strong></p> <p>Risk of lactic acidosis:</p> <ul> <li>Metformin hydrochloride may cause a very rare but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly, if you have uncontrolled diabetes, serious infections, liver problems, dehydration.</li> <li>Stop taking metformin hydrochloride and contact a doctor or the nearest hospital immediately if you experience some of the symptoms of lactic acidosis, as this condition may lead to coma.</li> </ul> <p>Symptoms of lactic acidosis:</p> <ul> <li>Vomiting</li> <li>Stomach ache</li> <li>Muscle cramps</li> <li>A general feeling of not being well with severe tiredness</li> <li>Difficulty in breathing</li> <li>Reduced body temperature and heartbeat</li> </ul> <p>Risk of hypoglycemia:</p> <ul> <li>If you take metformin hydrochloride together with other medicines to treat diabetes, that can cause hypoglycemia.</li> <li>If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders or difficulty in concentration, it usually helps to eat or drink something containing sugar.</li> </ul> <p>Possible side effects of metformin hydrochloride:</p> <ul> <li>All medicines can have side effects. Sometimes they are serious, most of the time they are not.</li> <li>You may need medical treatment if you get some of the side effects.</li> <li>Tell your doctor if you notice any of the following and they worry you:</li> <li>Lactic acidosis which can lead to coma</li> <li>Digestive problems such as nausea, vomiting, diarrhea, abdominal pain and loss of appetite</li> <li>Change in taste</li> </ul> <p>Other medicines and metformin hydrochloride:</p> <ul> <li>Tell your doctor if you are using, have recently used or might use any other medicines.</li> <li>Medicines which increase urine production (diuretics)</li> <li>Medicines used to treat pain and inflammation (nsaids)</li> <li>Certain medicines for the treatment of high blood pressure</li> <li>Beta-2 agonists such as salbutamol (to treat asthma)</li> <li>Corticosteroids</li> <li>Other medicines used to treat diabetes</li> </ul> <p><strong>Ingredients:</strong></p> <p>Its available with different strengths for multi manufacturers:</p> <p>500 mg:</p> <ul> <li>Each extended release tablet of XR 500 contains 500 mg metformin hydrochloride corresponding to 390 mg metformin base.</li> </ul> <p>750 mg:</p> <ul> <li>Each extended release tablet of XR 750 contains 750 mg metformin hydrochloride corresponding to 585 mg metformin base.</li> </ul> <p>1,000 mg:</p> <ul> <li>Each extended release tablet of XR 1000 mg contains 1000 mg metformin hydrochloride corresponding to 780 mg metformin base.</li> </ul>