Combigan Eye Drop 5 ml

 

What Brimonidine tartrate and timolol
is used for:

 It is an eye drop that is used to control
glaucoma.

Do
not use Brimonidine tartrate and timolol:

• if you are allergic
  (hypersensitive) to brimonidine tartrate, timolol, beta-blockers or any of the
  other ingredients of this medicine. Symptoms of an allergic reaction may
  include swelling of the face, lips and throat, wheeziness, feeling faint,
  shortness of breath, itching or redness around the eye
• if you have now or have had in
  the past respiratory problems such as asthma, severe chronic obstructive
  bronchitis (severe lung disease which may cause wheeziness, difficulty in
  breathing and/or long-standing cough)
• if you have heart problems
  such as low heart rate, heart failure, heart beat disorders (unless controlled
  by a pacemaker)
• if you are taking monoamine
  oxidase (MAO) inhibitors or certain other antidepressant drugs.

 

Warnings & Precautions:

You
should tell your doctor if you have any of the following:

• if you have now or have had in the past 
• coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure 
• disturbances of heart rate such as slow heart beat 
• breathing problems, asthma or chronic obstructive pulmonary disease  
• poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome) 
• diabetes as timolol may mask signs and symptoms of low blood sugar levels 
• over activity of the thyroid gland as timolol may mask signs and symptoms 
• kidney or liver problems 
• tumor of the adrenal gland 
• eye surgery to lower the pressure in your eye 
• if you suffer or have suffered from any allergy (e.g. hayfever, eczema) or a severe allergic reaction be aware that the usual dose of adrenaline used to control a severe reaction may need to be increased. 

Tell the
doctor before you have an operation that you are using it, as the timolol may
change effects of some medicines during anesthesia.

Possible Side Effects:

Like all medicines, Brimonidine
tartrate   can cause side effects, although
not everybody gets them. Stop using the product and seek immediate medical
attention if you develop throat tightness or swelling of the eyes, face, lips
or tongue, feel faint, or have difficulty breathing. Stop using the product if
you develop hives or itching of the face or body.

Other
medicines and Brimonidine tartrate and timolol:

Tell
your doctor or pharmacist if you are taking:

• pain
  killers
• medicines
  to help you sleep or for anxiety
• medicines
  to treat high blood pressure (hypertension)
• medicines
  for heart conditions (for example an abnormal heartbeat) such as beta blockers,
  digoxin or quinidine (used to treat heart conditions and some types of
  malaria) 
• medicines
  to treat diabetes or high blood sugar 
• medicines
  for depression such as fluoxetine and paroxetine
• another
  eye drop used to lower high pressure in the eye (glaucoma)
• medicines
  to treat severe allergic reactions
• medicines
  that affect some of the hormones in your body, like adrenaline and dopamine
• medicines
  that affect the muscles in your blood vessels
• medicines
  to treat heartburn or stomach ulcers

 How to use Brimonidine tartrate and timolol:

The recommended dose is one drop of
it, twice a day about 12 hours apart.  Do
not change the dose or stop taking it without speaking to your doctor.

If you have other eye drops, leave at
least 5 minutes between using it and the other eye drops.

 

How
to store Brimonidine tartrate and timolol:

• Keep this medicine out of the sight
  and reach of children.
• Do not use this medicine after the
  expiry date which is stated on the carton and label after ‘EXP’. The expiry
  date refers to the last day of that month.
• Do not store above 25°C. 
• Discard within 28 days of
  opening. 
• Do not throw away any medicines via wastewater
  or household waste. Ask your pharmacist how to throw away medicines you no
  longer use. These measures will help protect the environment.

Ingredients:

 Brimonidine tartrate and timolol 2 mg/ml + 5 mg/ml eye drops, solution